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​研究サポート

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科学研究費補助金

2022-2024 基盤研究(C) 腸内細菌叢の撹乱プロセスの理解と是正評価系の開発

2018-2020 基盤研究(C) ミルクを用いた乳幼児のための感染症予防素材の創出

2014-2015 若手研究(B) 感染細胞内で機能する牛乳ラクトフォリンのウイルス複製阻害機構の解明

2012-2013 若手研究(B) ウイルスへの直接結合によらない牛乳ラクトフォリンの示す感染阻害メカニズムの解明

2009  特別研究員奨励費(DC2)  食べ物による腸感染症のコントロール-牛乳タンパク質による予防と症状の軽減化-

​研究業績

​ひとつひとつ、真心込めて。

2024

Ishiguro, N., Hayashi, T.,  Okayama, M.  Yamaguchi, T., Kohno, M., Kawakami, H., Mitsunaga, T., Nakamura, K and Inagaki, M.: Effects of blackcurrant extract on indole and ammonia production in an in vitro human fecal culture model. Biosci Microbiota Food Health. 43:23-28, 2024.

2023

Sato, K., Jinno, S., Nakamura, Y., Eto, S., and Inagaki M.: Absolute quantification of bovine lactadherin to screen the anti-rotavirus activity of dairy ingredients. J Dairy Sci. 106:2261-2270, 2023.

2021

Kobayashi, C.,  Inagaki, M., Nohara, M., Fukuoka, M., Xijier, Yabe, T., and Kanamaru Y.: The effects of denatured major bovine whey proteins on the digestive tract, assessed by Caco-2 cell differentiation and on viability of suckling mice. J Dairy Res. 88: 221-225, 2021.

2020

Yamada, K.,  Nio-Kobayashi, J., and Inagaki, M.: Screening for components/compounds with anti-rotavirus activity: detection of interaction between viral spike proteins and glycans In: Lectin Purification and Analysis. Jun Hirabayashi ed. Springer US, pp. 585-595, 2020 (ISBN 978-1-07-160429-8).

2019

Shimada, M., Ichigo, Y., Shirouchi, B., Takashima, S., Inagaki, M., Nakagawa, T., and Hayakawa, T.: Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-beta and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. Nuts. Res. 64: 49-55, 2019.

 

遠藤江美:細胞シグナル伝達経路によるエンドソーム酸性化がロタウイルス脱殼を促す. ファルマシア55: 71, 2019.

 

2018

*Nakatsuchi, A., *Inagaki, M., Sugiyama, M., Usui, M. and Asai, T.: Association of Salmonella serotypes with quinolone resistance in broilers. Food Safety. 6: 156-159, 2018. *equal contribution

 

Nemoto, M., Inagaki, M., Tamura, N., Bannai, H., Tsujimura K., Yamanaka, T. and Kokado, H.: Evaluation of inactivated vaccines against equine group A rotaviruses by use of a suckling mouse model. Vaccine. 36: 5551-5555, 2018.

 

Kawada, Y., Goshima, T., Sawamura, R., Yokoyama, S., Yanase, E., Niwa, T., Ebihara, A., Inagaki, M., Yamaguchi, K., Kuwata, K., Kato. Y., Sakurada, O. and Suzuki, T.: Daizein reductase of Eggerthellasp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones. J. Biosci. Bioeng. 126: 301-309, 2018.

 

稲垣瑞穂,金丸義敬:乳成分を用いた受動免疫素材の可能性. ビタミン92: 424-426, 2018.

 

中川智行,内田みなみ,平井菜未,奥村真衣,吉村明浩,澤井美伯,正木和夫,二神泰基,玉置尚徳,向田潤,三井亮司,稲垣瑞穂,島田昌也,鈴木徹,杉山誠,早川享志: 新奇清酒酵母の開発に向けた岐阜県自然環境からの出芽酵母のスクリーニングとその清酒醸造特性. J. Brew. Soc. Japan. 113: 1-10, 2018.

 

2017

Inagaki, M.,Kawai, S.,Xijier, Fukuoka, M., Yabe, T., Iwamoto, S.and Kanamaru, Y.: Effects of heat treatment on conformation and cell growth activity of alpha-lactalbumin and beta-lactoglobulin from market milk. Biomed. Res. 38: 53-59, 2017.

 

Tahoun, A., Masutani, H., El-Sharkawy, H., Gillespie, T., Honda, R. P., Kuwata, K., Inagaki, M., Yabe, T., Nomura, I. and Suzuki, T.: Capsular polysaccharide inhibits adhesion of Bifidobacterium longum105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages. Gut Pathog. 9: 27, 2017.

 

2015

Yamauchi, K., Mitsunaga,T., Inagaki, M. and Suzuki, T.: Quercetin derivatives regulate melanosome transportation viaEPI64 inhibition and elongate the cell shape of B16 melanoma cells. Biomed. Pharmacother. 70: 206-212, 2015.

 

2014

Inagaki, M.,Muranishi, H., Yamada, K., Kakehi, K., Uchida, K., Suzuki, T., Yabe, T., Nakagomi, T., Nakagomi, O. and Kanamaru, Y.: Bovine κ-casein inhibits human rotavirus (HRV) infection via direct binding of glycans to HRV. J. Dairy Sci.97: 2653-2661, 2014.

Yamauchi, K., Mitsunaga,T., Inagaki, M. and Suzuki, T.: Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. Bioorg. Med. Chem.22: 3331-3340, 2014.

 

Inagaki, M., Yabe, T. and Kanamaru, Y.: The potential of cow’s milk proteins for prophylaxis against intestinal infection. In: Whey Proteins: Functional Properties, Production and Health Benefits. Michelle Wyatt ed. Nova Science Publishers, Inc., NewYork, pp. 163-177,2014 (ISBN 978-1-63463-116-7).

 

~2013

Inagaki, M., Yamamoto, M., Cairangzhuoma, Xijier, Yabe, T., Uchida, K., Kawasaki, M., Nakagomi, T., Nakagomi, O., Minamoto, N. and Kanamaru, Y.: Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease. J. Dairy Sci.96: 806-814, 2013.

 

Cairangzhuoma, Yamamoto, M., Xijier, Inagaki, M., Uchida, K., Yamashita, K., Saito, S., Yabe, T. and Kanamaru, Y.: A preparation of cow's late colostrum fraction containing αs1-casein promoted the proliferation of cultured rat intestinal IEC-6 epithelial cells. Biosci. Biotechnol. Biochem.77: 992-997, 2013.

 

Inagaki, M., Xijier, Nakamura, Y., Takahashi, T., Yabe, T., Nakagomi, T., Nakagomi, O. and Kanamaru, Y.: Production and functional properties of dairy products containing lactophorin and lactadherin. In: Food Additive. Yehia El-Samragy ed. InTech, Rijeka, pp. 49-64, 2012 (ISBN 978-953-51-0067-6).

 

Xijier, Mori, Y., Fukuoka, M., Cairangzhuoma, Inagaki, M., Iwamoto, S., Yabe, T. and Kanamaru, Y.: Comparison of the efficacy of alpha-lactalbumin from equine, bovine, and human milk in the growth of intestinal IEC-6 cells. Biosci. Biotechnol. Biochem.76: 843-846, 2012.

 

稲垣瑞穂, 金丸義敬: ロタウイルス下痢症に対する牛乳タンパク質の利用性 . ミルクサイエンス60: 25-38, 2011.

 

Xijier, Inagaki, M., Kishita, K., Yabe, T.and Kanamaru, Y.: An assay for detecting neutralization of rotavirus infection by quantitative determination of VP6 protein fluorescence intensity. Biosci. Biotechnol. Biochem. 75: 2059-2062, 2011.

 

Inagaki, M., Nagai, S., Yabe, T., Nagaoka, S., Minamoto, N., Takahashi, T., Matsuda, T., Nakagomi, O., Nakagomi, T., Ebina, T. and Kanamaru, Y.: The bovine lactophorin C-terminal fragment and PAS6/7 were both potent in the inhibition of human rotavirus replication in cultured epithelial cells and the prevention of experimental gastroenteritis. Biosci. Biotechnol. Biochem.74: 1386-1390, 2010.

 

Inagaki, M., Yamamoto, M., Xijier, Cairangzhuoma, Uchida, K., Yamaguchi, H., Kawasaki, M., Yamashita, K., Yabe, T. and Kanamaru, Y.: In vitroand in vivoevaluation of the efficacy of bovine colostrum against human rotavirus infection. Biosci. Biotechnol. Biochem.74: 680-682, 2010.

 

Inagaki, M., Nakaya, S., Nohara, D., Yabe, T., Kanamaru, Y. and Suzuki, T.: The multiplicity of N-glycan structures of bovine milk 18 kDa lactophorin (milk GlyCAM-1). Biosci. Biotechnol. Biochem. 74: 447-450, 2010.

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